γ-Glutamyl Transferase (GGT)

γ-Glutamyl Transferase, Gamma-Glutamyl Transferase

Gamma-glutamyl transferase (GGT) is a membrane-bound enzyme that plays a crucial role in Meister’s γ-glutamyl cycle, catabolizing reduced glutathione into cysteine and glycine. It anchors to the cell membrane via its N-terminus, with catalytic activity in the extracellular domain. GGT can remove the γ-glutamyl group from various extracellular substrates like proteins by cleaving γ-carboxyl bonds of glutamate. This enzyme is vital for glutathione homeostasis and mercapturic acid metabolism. Elevated serum GGT levels are significant markers for liver diseases, such as hepatitis C, cholestatic syndromes, and alcohol-related liver disease, as well as atherosclerotic cardiovascular disease^[1].

References:

[1]. Amedeo Lonardo, et al. Concise review: gamma-glutamyl transferase - evolution from an indiscriminate liver test to a biomarker of cardiometabolic risk. Metab Target Organ Damage 2022;2:17.

γ-Glutamyl Transferase (GGT) Inhibitors (9)

γ-Glutamyl Transferase (GGT) Related Products (11):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-108467

GGsTop	Inhibitor	99.35%
GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a K_i of 170 μM for Human GGT. GGsTop shows a pK_a of 9.71, also exhibits K_ons of 150 and 51 M^-1 s^-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.

HY-W016586

Acivicin	Inhibitor	99.00%
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

HY-128350A

FGTI-2734 mesylate	Inhibitor	99.65%
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.

HY-126710

OU749	Inhibitor	98.83%
OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a K_i value of 17.6 µM. OU749 shows cytotoxicity.

HY-154996

Gamma-Glutamyl Transferase-IN-2	Inhibitor
Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.

HY-W016586R

Acivicin (Standard)	Inhibitor
Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway.

HY-154993

Gamma-Glutamyl Transferase-IN-1	Inhibitor
Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.

HY-146343

BMI-Glu
BMI-Glu is a selective γ-glutamyl transpeptidase (GGT) fluorescent probe with a K_m of 69.63 µM. BMI-Glu has high sensitivity, good water solubility and biocompatibility.

HY-P2997A

γ-glutamyltransferase, Human liver
γ-glutamyltransferase, Human liver (GGT, Human liver) is an enzyme located on the outer surface of the cell membrane. γ-glutamyltransferase, Human liver maintains the physiological concentration of cytoplasmic glutathione and the cell's defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. γ-glutamyltransferase, Human liver is used for pancreatic cancer research.

HY-W142025

6-Diazo-5-oxo-D-norleucine	Inhibitor
6-Diazo-5-oxo-D-norleucine, a D-Glutamine (HY-100587) analog, is a γ-glutamyl transferase inhibitor.

HY-W016586AR

Acivicin hydrochloride (Standard)	Inhibitor
Acivicin (hydrochloride) (Standard) is the analytical standard of Acivicin (hydrochloride). This product is intended for research and analytical applications. Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

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